Ym1 protein crystals promote type 2 immunity
Spontaneous protein crystallization is a rare event, yet protein crystals are frequently found in eosinophil-rich inflammation.In humans, Charcot-Leyden crystals (CLCs) are made from galectin-10 (Gal10) protein, an abundant protein in eosinophils.Although mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-li